Education:
MS 1998 Biochemistry - University of Zurich, Switzerland
PhD 2002 Biochemistry - University of Oxford, England
Postdoctoral Research Fellowship:
2002 - 2005 National Institutes of Health, Bethesda, MD
Started at USC: 2005
Research Topics: Signal Transduction, Aging, Structural Biology
Research Description
The main focus of my research is the study of proteins that are embedded in the cell membrane or associate with its surface (membrane proteins) using NMR spectroscopy to elucidate their 3D structures at atomic resolution. By controlling the exchange of information and metabolites between cells and the extracellular matrix membrane proteins regulate critical biological processes such as cell adhesion, development and signaling. Malfunction and misfolding of membrane proteins are often associated with prevalent diseases such as cancer and Parkinson’s and most pharmaceutical drugs target membrane proteins.
Please visit the group homepage for more information
http://resonance.usc.edu/
LEGEND TO PHOTO: (below)
The photo shows Dr. Ulmer standing by the nuclear magnetic resonance (NMR) spectrometer in the basement of the Zilkha Neurogenetic Institute. (Photo by Monika Guttman)
10 Selected Publications:
Click here to view all the publications for this faculty
Hung KC,Mac TT,Ulmer TS - NMR assignment of the periplasmic oxidoreductase DsbH from Chlamydia. - Biomol NMR Assign [2007] Dec;1(2):195-6 PubMed
Rao JN,Kim YE,Park LS,Ulmer TS - Effect of Pseudorepeat Rearrangement upon alpha-Synuclein Misfolding,Vesicle Binding and Micelle Binding. - J Mol Biol [2009] May 26;(): PubMed
Lau TL,Kim C,Ginsberg MH,Ulmer TS - The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. - EMBO J [2009] Mar 12;(): PubMed
Kim C,Lau TL,Ulmer TS,Ginsberg MH - Interactions of platelet integrin {alpha}IIb and {beta}3 transmembrane domains in mammalian cell membranes and their role in integrin activation. - Blood [2009] Feb 13;(): PubMed
Lau TL,Dua V,Ulmer TS - Structure of the integrin alphaIIb transmembrane segment. - J Biol Chem [2008] Jun 6;283(23):16162-8 PubMed
Rao JN,Dua V,Ulmer TS - Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules. - Biochemistry [2008] Apr 22;47(16):4651-6 PubMed
Lau TL,Partridge AW,Ginsberg MH,Ulmer TS - Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles. - Biochemistry [2008] Apr 1;47(13):4008-16 PubMed
Mac TT,von Hacht A,Hung KC,Dutton RJ,Boyd D,Bardwell JC,Ulmer TS - Insight into disulfide bond catalysis in Chlamydia from the structure and function of DsbH, a novel oxidoreductase. - J Biol Chem [2008] Jan 11;283(2):824-32 PubMed
Ulmer TS,Bax A - Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants. - J Biol Chem [2005] Dec 30;280(52):43179-87 PubMed
Jaroniec CP,Ulmer TS,Bax A - Quantitative J correlation methods for the accurate measurement of 13C'-13Calpha dipolar couplings in proteins. - J Biomol NMR [2004] Oct;30(2):181-94 PubMed
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