Education:
AB 1996 Chemistry - Harvard University
PhD 2001 Chemistry - California Institute of Technology, Pasadena
Postdoctoral Research Fellowship:
2001 - 2003 Stanford University, California
Started at USC: 2003 Research Topics: Natural Products Biosynthesis, Gene Regulation, Fungal Secondary Metabolism, Metabolic Engineering
Research Description The primary focus of my lab is to use an interdisciplinary approach to study natural product biosynthesis. We are interested in studying two aspects of natural product chemistry 1) development of a heterologous host for natural product production and 2) discovery of natural products and their biosynthesis pathways in a fungal genome. Both of these topics are significant because recent advances in genome sequencing have provided a large amount of sequence information. My research seeks to leverage this information into drug discovery that can ultimately benefit human health.
10 Selected Publications:
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Watanabe K,Hotta K,Praseuth AP,Searcey M,Wang CC,Oguri H,Oikawa H - Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli. - Chembiochem [2009] Aug 17;10(12):1965-8 PubMed
Watanabe K,Hotta K,Nakaya M,Praseuth AP,Wang CC,Inada D,Takahashi K,Fukushi E,Oguri H,Oikawa H - Escherichia coli Allows Efficient Modular Incorporation of Newly Isolated Quinomycin Biosynthetic Enzyme into Echinomycin Biosynthetic Pathway for Rational Design and Synthesis of Potent Antibiotic Unnatural Natural Product. - J Am Chem Soc [2009] Jun 10;(): PubMed
Bok JW,Chiang YM,Szewczyk E,Reyes-Domingez Y,Davidson AD,Sanchez JF,Lo HC,Watanabe K,Strauss J,Oakley BR,Wang CC,Keller NP - Chromatin-level regulation of biosynthetic gene clusters. - Nat Chem Biol [2009] May 17;(): PubMed
Chiang YM,Szewczyk E,Davidson AD,Keller N,Oakley BR,Wang CC - A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans. - J Am Chem Soc [2009] Feb 6;(): PubMed
Praseuth AP,Wang CC,Watanabe K,Hotta K,Oguri H,Oikawa H - Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus. - Biotechnol Prog [2008] Nov-Dec;24(6):1226-31 PubMed
Szewczyk E,Chiang YM,Oakley CE,Davidson AD,Wang CC,Oakley BR - Identification and characterization of the asperthecin gene cluster of Aspergillus nidulans. - Appl Environ Microbiol [2008] Dec;74(24):7607-12 PubMed
Wang CC,Chiang YM,Kuo PL,Chang JK,Hsu YL - Norsolorinic acid inhibits proliferation of T24 human bladder cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a fas/membrane-bound Fas ligand-mediated apoptotic pathway. - Clin Exp Pharmacol Physiol [2008] Nov;35():1301-8 PubMed
Hsu CF,Phillips JW,Trauger JW,Farkas ME,Belitsky JM,Heckel A,Olenyuk BZ,Puckett JW,Wang CC,Dervan PB - Completion of a Programmable DNA-Binding Small Molecule Library. - Tetrahedron [2007] Jul 2;63(27):6146-6151 PubMed
Chiang YM,Szewczyk E,Nayak T,Davidson AD,Sanchez JF,Lo HC,Ho WY,Simityan H,Kuo E,Praseuth A,Watanabe K,Oakley BR,Wang CC - Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway. - Chem Biol [2008] Jun;15(6):527-32 PubMed
Wang CC,Chiang YM,Kuo PL,Chang JK,Hsu YL - Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway. - Basic Clin Pharmacol Toxicol [2008] Jun;102():491-7 PubMed
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