| Send E-mail to: clayw@usc.edu | |
| Telephone: 323-442-1670 | Fax: 323-442-1365 |
| Office: PSC 704 | Mail Code: 9121 HSC |
Education:
AB 1996 Chemistry- Harvard University
PhD 2001 Chemistry- California Institute of Technology, Pasadena
Postdoctoral Research Fellowship:
2001-2003 Stanford University, California
Started at USC: 2003
Research Topics: Gene Regulation/Transcription, Drug Design, Delivery, DNA & RNA
Research Description
-chemical approaches toward gene regulation
-bioengineering and biosynthesis of natural products
Wang Group Research Projects
1. Chemical approaches toward gene regulation
Elucidation of gene function is an important task in this post genome era. We are interested in designing chemical probes that would allow us to turn off gene expression. We would like our chemical probes to possess three features (1) generally applicable (2) externally controllable (3) orthogonally inducible. We hope to use our chemical probes to study cell cycle regulators that play critical roles in cancers.
2. Bioengineering of polyketide natural products
We are interested in understanding how nature synthesizes important anti cancer agents. Using molecular biology and chemistry, we hope to reengineer these biosynthetic pathways in order to create new anti tumor agents.
Selected Publications
Pfeifer BA, Wang CC, Walsh CT, Khosla C. - Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. - Appl Environ Microbiol [ 2003 ] Nov;69(11):6698-702 . PubMed
Watanabe K, Wang CC, Boddy CN, Cane DE, Khosla C. - Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. - J Biol Chem [ 2003 ] Oct 24;278(43):42020-6 . PubMed
