| Send E-mail to: lweiner@usc.edu | | | Telephone: 323-442-3020 | Fax: 323-442-3015 | | Office: KAM 410 | Mail Code: 9031 HSC |
Education:
BA 1957 - Wilkes College, Wilkes-Barre, Pennsylvania
MD 1961 - University of Cincinnati College of Medicine, Cincinnati, Ohio
Started at USC: 1975 Research Topics: Neurogenetics, Immunology
Research Description The research in this laboratory has been primarily related to the pathogenesis of viral infections, especially mouse coronaviruses and pathogenesis of demyelination in a murine model. We have a strong interest in the neuroendocrine influences on the immune response, in relation to brain peptides and the production of lymphokines. Newer work has been concentrated on the molecular and genetic mechanisms of degenerative disease of the nervous system. Our most recent effort is in restoring tolerance to myelin antigens in human and mouse models. We are administering a USC T cell vaccine to multiple sclerosis patients and studying the induction of tolerance by gene therapy.
10 Selected Publications:
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Hawker K,O'Connor P,Freedman MS,Calabresi PA,Antel J,Simon J,Hauser S,Waubant E,Vollmer T,Panitch H,Zhang J,Chin P,Smith CH,OLYMPUS trial group - Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial. - Ann Neurol [2009] Oct;66(4):460-71 PubMed
Zhong JF,Weiner LP,Jin Y,Lu W,Taylor CR - A real-time pluripotency reporter for human stem cell. - Stem Cells Dev [2009] May 27;(): PubMed
Duncan ID,Goldman S,Macklin WB,Rao M,Weiner LP,Reingold SC - Stem cell therapy in multiple sclerosis: promise and controversy. - Mult Scler [2008] May;14(4):541-6 PubMed
Weiner LP - Definitions and criteria for stem cells. - Methods Mol Biol [2008] ;438():3-8 PubMed
Zhong JF,Chen Y,Marcus JS,Scherer A,Quake SR,Taylor CR,Weiner LP - A microfluidic processor for gene expression profiling of single human embryonic stem cells. - Lab Chip [2008] Jan;8(1):68-74 PubMed
Zhong JF,Song Y,Du J,Gamache C,Burke KA,Lund BT,Weiner LP - Gene regulation networks related to neural differentiation of hESC. - Gene Expr [2007] ;14(1):23-34 PubMed
Zhong JF,Weiner LP,Burke K,Taylor CR - Viral RNA extraction for in-the-field analysis. - J Virol Methods [2007] Sep;144(1-2):98-102 PubMed
Gross PG,Weiner LP,Kartalov EP,Scherer A - Microfluidic techniques for studying the nervous system. - Crit Rev Neurobiol [2005] ;17(3-4):119-44 PubMed
Gross PG,Kartalov EP,Scherer A,Weiner LP - Applications of microfluidics for neuronal studies. - J Neurol Sci [2007] Jan 31;252(2):135-43 PubMed
Louie KA,Weiner LP,Du J,Kochounian HH,Fling SP,Wei W,McMillan M - Cell-based gene therapy experiments in murine experimental autoimmune encephalomyelitis. - Gene Ther [2005] Jul;12(14):1145-53 PubMed
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