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| Send E-mail to: qying@usc.edu | | | Telephone: 323-442-3308 | Fax: 323-442-4040 | | Office: ZNI 529 | Mail Code: 2821 HSC |
Education:
BSc 1987 Medicine - The First Military Medical University, China
MSc 1992 Neurosurgery - Shanghai Medical University, China
PhD 1995 Neurology - Shanghai Medical University, China
Postdoctoral Research Fellowship:
1995 - 1998 Shanghai Medical University
1999 - 2006 University of Edinburgh, UK
Started at USC: 2006 Research Topics: Cellular Neurobiology, Developmental Biology, Signal Transduction, Stem Cell Biology
Research Description
Embryonic stem (ES) cells are remarkable cell lines that are derived from the inner cell mass of pre-implantation embryos. They can be grown indefinitely in culture while retaining the capacity to differentiate into all the cells of the body. When reintroduced into early stage embryos, ES cell can reenter normal developmental processes and contribute to all lineages including germ cells. This differentiation potential makes ES cells a possible source for future cell replacement therapies. The process in which pluripotent ES cells differentiate into progenitors with a more restricted developmental potential and then to terminally differentiated cells is predictable and controllable. This means ES cells are also an ideal model for the study of the molecular and epigenetic events that occur during this differentiation process.
My research focuses on understanding the molecular mechanism underlying ES cell self-renewal and differentiation. When an ES cell divides it can either produce identical copies of itself (self-renewal) or it can produce other more specialized cell types (differentiation) such as neurons. Understanding how an ES cell makes this choice between self-renewal and differentiation is the central challenge in stem cell research. We recently identified a novel regulatory pathway that promotes the multiplication of pure populations of mouse embryonic stem cells. This discovery allowed for the first time growth of embryonic stem cells in fully defined medium. I am also interested in finding out the molecular basis underlying the difference between mouse and human ES cells in their requirement for extrinsic stimuli that sustain pluripotency
10 Selected Publications:
Click here to view all the publications for this faculty
Li P,Tong C,Mehrian-Shai R,Jia L,Wu N,Yan Y,Maxson RE,Schulze EN,Song H,Hsieh CL,Pera MF,Ying QL - Germline competent embryonic stem cells derived from rat blastocysts. - Cell [2008] Dec 26;135(7):1299-310 PubMed
Buehr M,Meek S,Blair K,Yang J,Ure J,Silva J,McLay R,Hall J,Ying QL,Smith A - Capture of authentic embryonic stem cells from rat blastocysts. - Cell [2008] Dec 26;135(7):1287-98 PubMed
Ying QL,Wray J,Nichols J,Batlle-Morera L,Doble B,Woodgett J,Cohen P,Smith A - The ground state of embryonic stem cell self-renewal. - Nature [2008] May 22;453(7194):519-23 PubMed
Nichols J,Ying QL - Derivation and propagation of embryonic stem cells in serum- and feeder-free culture. - Methods Mol Biol [2006] ;329():91-8 PubMed
Conti L,Pollard SM,Gorba T,Reitano E,Toselli M,Biella G,Sun Y,Sanzone S,Ying QL,Cattaneo E,Smith A - Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. - PLoS Biol [2005] Sep;3(9):e283 PubMed
Ying QL,Smith AG - Defined conditions for neural commitment and differentiation. - Methods Enzymol [2003] ;365():327-41 PubMed
Ying QL,Nichols J,Chambers I,Smith A - BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. - Cell [2003] Oct 31;115(3):281-92 PubMed
Ying QL,Stavridis M,Griffiths D,Li M,Smith A - Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. - Nat Biotechnol [2003] Feb;21(2):183-6 PubMed
Billon N,Jolicoeur C,Ying QL,Smith A,Raff M - Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells. - J Cell Sci [2002] Sep 15;115(Pt 18):3657-65 PubMed
Ying QL,Nichols J,Evans EP,Smith AG - Changing potency by spontaneous fusion. - Nature [2002] Apr 4;416(6880):545-8 PubMed
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