| Send E-mail to: zeichner@usc.edu | |
| Telephone: 323-442-3167 | Fax: 323-442-2981 |
| Office: CSA 106 | Mail Code: 9062 HSC |
Education:
BS 1968 Chemistry/Biology - Iberoamericana University, Mexico
PhD 1974 Cell Biology - National Polytechnic Institute, Mexico City, Mexico
Postdoctoral Research Fellowship:
1974 - 1977 National Institute of Dental Research, National Institute of Health, Bethesda, Maryland
Started at USC: 1977
Research Topics: Developmental Biology
Research Description
"Biology of Connective Tissues, Bones & Teeth"
The long term objective of this project was to determine the structure and function of enamel proteins in tissue-specific biomineralization (amelogenin and tuftelin) as well as the molecular genetics of Amelogenesis Imperfecta.
"Cementogenesis: Role of Hertwig's Epithelial Root Sheath"
The long-term objective of this project is to test the hypothesis that HERS cells undergo epithelial-mesenchymal transformation to become cementoblast cells which in turn deposit the cementum covering the roots.
"Molecular Determinants of Root Resorption"
This is a small grant designed to obtain preliminary data to study the initial molecular events leading to external root resorption induced by endodontic treatment.
"Tissue Engineering for Periodontium Repair"
The long-term objective of this project is to test the hypothesis that HERS cells (or their products) can be used in tissue engineering to regenerate periodontal tissue.
10 Selected Publications:
Click here to view all the publications for this faculty
Villarreal-RamÃrez E,Moreno A,Mas-Oliva J,Chávez-Pacheco JL,Narayanan AS,Gil-ChavarrÃa I,Zeichner-David M,Arzate H - Characterization of recombinant human cementum protein 1 (hrCEMP1): Primary role in biomineralization. - Biochem Biophys Res Commun [2009] Apr 23;(): PubMed
Carmona-Rodríguez B,Alvarez-Pérez MA,Narayanan AS,Zeichner-David M,Reyes-Gasga J,Molina-Guarneros J,García-Hernández AL,Suárez-Franco JL,Chavarría IG,Villarreal-Ramírez E,Arzate H - Human Cementum Protein 1 induces expression of bone and cementum proteins by human gingival fibroblasts. - Biochem Biophys Res Commun [2007] Jul 6;358(3):763-9 PubMed
Catón J,Bringas P Jr,Zeichner-David M - Establishment and characterization of an immortomouse-derived odontoblast-like cell line to evaluate the effect of insulin-like growth factors on odontoblast differentiation. - J Cell Biochem [2007] Feb 1;100(2):450-63 PubMed
Zeichner-David M - Regeneration of periodontal tissues: cementogenesis revisited. - Periodontol 2000 [2006] ;41():196-217 PubMed
Zeichner-David M,Chen LS,Hsu Z,Reyna J,Caton J,Bringas P - Amelogenin and ameloblastin show growth-factor like activity in periodontal ligament cells. - Eur J Oral Sci [2006] May;114 Suppl 1():244-53; discussion 254-6, 381-2 PubMed
Jerome J,Brunson T,Takeoka G,Foster C,Moon HB,Grageda E,Zeichner-David M - Celebrex offers a small protection from root resorption associated with orthodontic movement. - J Calif Dent Assoc [2005] Dec;33(12):951-9 PubMed
Alvarez-Pérez MA,Narayanan S,Zeichner-David M,Rodríguez Carmona B,Arzate H - Molecular cloning, expression and immunolocalization of a novel human cementum-derived protein (CP-23). - Bone [2006] Mar;38(3):409-19 PubMed
Plikus MV,Zeichner-David M,Mayer JA,Reyna J,Bringas P,Thewissen JG,Snead ML,Chai Y,Chuong CM - Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. - Evol Dev [2005] Sep-Oct;7(5):440-57 PubMed
Catón J,Bringas P Jr,Zeichner-David M - IGFs increase enamel formation by inducing expression of enamel mineralizing specific genes. - Arch Oral Biol [2005] Feb;50(2):123-9 PubMed
Ravindranath HH,Chen LS,Zeichner-David M,Ishima R,Ravindranath RM - Interaction between the enamel matrix proteins amelogenin and ameloblastin. - Biochem Biophys Res Commun [2004] Oct 22;323(3):1075-83 PubMed
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