USC Directory Entry

Helena Chui

M.D.: The Johns Hopkins University School of Medicine, Baltimore, Maryland, 1977. Residency: Neurology, University of Iowa College of Medicine, Iowa City, Iowa, 1979-1982. Fellowship: Department of Behavioral Neurology, University of Iowa College of Medicine, Iowa City, Iowa, 1978.

Dr. Chui's research focuses on brain-behavior correlations in dementia. Her publications have examined clinical heterogeneity, natural history, clinical diagnosis, and clinical-pathologic correlations in Alzheimer Disease (AD) and ischemic vascular dementia. Over 1400 patients, evaluated at the Alzheimer Disease Diagnostic and Treatment Center since 1985, have been entered into a clinical database. In addition, quantitative neuropathologic assessments for over 200 cases of these cases who have come to autopsy have been entered into a pathological database. As an example of clinical-pathological correlation, agitation in AD was recently found to be correlated with relative preservation of neurons in the substantia nigra pars compacta. Dr. Chui was recently awarded a five-year grant by the NIA to study ischemic vascular dementia, the second most common cause of dementia. The overreaching goal of this multi-institutional program project relates to diagnosis and natural history of vascular dementia. The individual research project headed by Dr. Chui examines the pathophysiologic and functional significance of deep white matter changes and pathological correlates of ischemic lesions visualized by MRI.

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