USC Directory Entry
Professor David Z. D'Argenio
David Z. D'Argenio received his Bachelors degree in Electrical
Engineering from the University of Dayton in 1972, M.S. in Electrical
Engineering from the Pennsylvania State University in 1974, and
Ph.D. in Biomedical Engineering from USC in 1979. He was an American
Heart Association Fellow in cardiology at USC in 1979. During 1988,
Dr. D'Argenio was a Visiting Scientist at Saint Jude Children's
Research Hospital in Memphis. From 1993 to 1995 he served as Associate
Dean for Academic Affairs in the School of Engineering, and since
1996 he has been the Chairman of the Department of Biomedical Engineering.
Dr. D'Argenio is Co-Director, together with Vasilis Z. Marmarelis,
of the Biomedical Simulations Resource (BMSR) at USC. The BMSR is
funded by the National Center for Research Resources of the NIH
to develop advanced methods for biomedical modeling and simulation
for use by the biomedical research community.
Dr. D'Argenio's research focuses on the development of advanced
modeling and computational methods for studying the absorption,
distribution and elimination of therapeutic drugs (pharmacokinetics)
and for understanding how drugs produce their effects (pharmacodynamics).
Recent research projects include:
- Modeling Drug Interactions of anti-cancer and anti-viral drugs
- Nonlinear Bayesian Forcasting using Markov Chain Monte Carlo
- Pharmacodynamic Model of Warfarin's Action on Clotting Factors
- Topotecan Kinetics in Tumors from Microdialysis Data
- Control of Uncertain Pharmacodynamics Processes with Application
- Cellular Kinetics of the Anti-Viral Agents PMPA and PMEA
- Targeting the systemic exposure of the anticancer drug Teniposide
- A model of intestinal phosphate absorption from in vivo
- Neural networks for nonlinear Bayesian estimation
- Modeling Tc-99m DMSA kinetics from imaging data
- Stochastic control of Theophylline therapy
- Adaptive control of Amioglyioside antibiotics
- Optimal sampling times for pharmacokinetic experiments
Dr. D'Argenio has also developed, together with Dr. Alan Schumitzky
of the Department of Mathamatics at USC, the ADAPT software package
for pharmacokinetic/pharmacodynamic systems analysis. ADAPT is a
computational tool for basic and clinical research scientists involved
in therapeutic drug development. It is designed to facilitate the
discovery, exploration and application of the underlying pharmacokinetic
and pharmacodynamic properties of therapeutic drugs.
Drusano, G.L., D.Z. D'Argenio, S.L. Preston, C. Barone, W. Symonds,
S. LaFon, M. Rogers, W. Prince, A. Bye & J.A. Bilello. Use of
drug effect interaction modeling with Monte Carlo simulation to
examine the impact of dosing interval on the projected antiviral
activity of the combination of Abacavir and Amprenavir. Antimicrobial
Agents in Chemotherapy, 44:1655-1659, 2000.
Snyder, S., D.Z. D'Argenio, O. Weislow, J.A. Bilello & G.L.
Drusano. The triple combination of indivavir, zidovudine plus
lamivudine is highly synergistic. Antimicrobial Agents in Chemotherapy,
Drusano, G.L., D.Z. D'Argenio, W. Symonds, P.A. Bilello, J.
McDowell, B. Sadler, A. Bye & J.A. Bilello. Nucleoside analog
1592U89 and human immunodeficiency virus protease inhibitor 141W94
are synergistic in vitro. Antimicrobial Agents & Chemotherapy,
D'Argenio, D.Z. & K.S. Park. Pharmakokinetic/pharmacodynamic
systems: Design, estimation and control. Control Engineering
Practice, 5:1707- 1716, 1997.
D'Argenio, D.Z. & A. Schumitzky. ADAPT II User's Guide:
Pharmacokinetic/Pharmacodynamic Systems Analysis Software. Biomedical
Simulations Resource, Los Angeles, 1997.
Siebes, M., C.S. Campbell & D.Z. D'Argenio. Fluid dynamics
of partially collapsible stenosis in a flow model of the coronary
circulation. J. of Biomechanical Eng., 118:489-497, 1996.
D'Argenio, D.Z. (ed.). Advanced Methods of Pharmacokinetic
and Pharmacodynamic Systems Analysis Vol II, Plenum Press, New
D'Argenio, D.Z., & J.H. Rodman. Targeting the systemic exposure
of Teniposide in the population and the individual using a stochastic
therapeutic objective. J. Pharmacokin. Biopharm., 21:223-251,
Kayne, L.H., D.Z. D'Argenio, et al. Analysis of segmental
phosphate absorption in intact rats. J. Clin. Inv., 91:915-922,
D'Argenio, D.Z. (ed.) Advanced Methods of Pharmacokinetic
and Pharmacodynamic Systems Analysis, Vol. I. Plenum Press,
New York, 1991.
D'Argenio, D.Z. Incorporating prior parameter uncertainty
in the design of sampling schedules for pharmacokinetic parameter
estimation experiments. Math. Biosc., 99:105-118, 1990.