USC Directory Entry

Caleb Finch Ph.D.

ARCO/ Keischnick Professor of Gerontology and Biological Sciences with adjunct appointments in the Department of Psychology, Department of Physiology and Department of Neurology. He is also one of USC’s 12 University Professors. Dr. Finch's major research interest is the study of genomic controls of mammalian development and aging. He received his undergraduate degree from Yale in 1961, where he majored in biophysics. He continued his work in cell biology and received his Ph.D. from Rockefeller University in 1969.

Dr. Finch has received most of the major awards in biomedical gerontology, including the Robert W. Kleemeier Award of the Gerontological Society of America in 1985, the Sandoz Premier Prize by the International Geriatric Association in 1995, and the Irving Wright Award of AFAR and the Research Award of AGE in1999. He has directed the NIA-funded Alzheimer Disease Research Center since 1984 and now serves as Co-Director with Dr. Helena Chui. Dr. Finch became a University Professor in 1989, an honor held by only 12 other professors at USC who contribute to multiple fields.

Dr. Finch supervises multiple predoctoral and postdoctoral fellows and two research faculty members. He is a member of ten editorial boards. He has written over 400 articles. In 1990 he published a major intellectual synthesis of aging: Longevity, Senescence, and the Genome. In 1995, Dr. Finch and Robert Ricklefs published Aging: A Natural History (Scientific American Library Series) for the general public. It has been translated into five different languages. His latest book, co-authored with Thomas Kirkwood was published by Oxford in 2000: Chance, Development, and Aging.


AWARDS

Finch wins Sandoz Award, gerontology's highest prize
Dr. Finch (Quicktime Movie 4.3 megs)


Recent papers:

Gong Y, Chang, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL (2003) Alzheimer-affected brain: Presence of oligomeric Aß ligand (ADDLs) suggests a molecular basis for reversible memory loss. PNAS, 100:10417-422. (Reprint)

Horiuchi S, Finch CE, Mesle F, and Vallin J (2003) Differential Patterns of Age-Related Mortality Increase in Middle Age and Old Age. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 58:A495-A507. (Reprint)

Xie Z, Morgan TE, Rozovsky I, Finch CE (2003) Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity. Experimental Neurology, 182:135–141. (Reprint)

Finch CE, Morgan TE (2003) Inflammatory Processes of Alzheimer Disease and Aging. Proc. Indian Natn Sci Acad. B69(2):165-178 (Reprint)

Longo V, Finch CE (2003) Evolutionary medicine from starvation and dwarf model systems to healthy centenarians. Science 299:1342-46. (Reprint)

Kirkwood TBL, Finch CE (2002) The old worm more slowly turns: (News and Views). Nature 419: 794-5. (Reprint)

Finch CE (2002) Neurons, Glia, and Plasticity in Normal Brain Aging. In, IHF Workshop on Brain and Behavior in Different Stages of Human Life. Adv Gerontol 10:35-9. (Reprint)

Longo W, Finch CE (2002) The genetics of aging and diseases: from rare mutations and model systems to disease prevention. Arch Neurol. 59:1706-8. (Reprint)

Finch CE, Morgan TE, Rozovsky I, Xie Z, Weindruch R, Prolla T (2002) Microglia and aging in the brain. In: Microglia in the degenerating and regenerating CNS (Streit WJ, ed.). Springer-Verlag. (Reprint)

Patel NV, Finch CE (2002) The glucocorticoid paradox of caloric restriction in slowing brain aging. Neurobiol Aging 23: 707-717. (Reprint)

Wilson CJ, Finch CE, Cohen HJ (2002). Cytokines and cognition--the case for a head-to-toe inflammatory paradigm. J Am Geriatr Soc. 50:2041-56. (Reprint)

 

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