Dr. Michael Jakowec, PhD, is Assistant Professor of Neurology and Biokinesiology & Physical Therapy at USC. He has been a member and ad hoc reviewer for the U.S. Army Parkinson's and Neurotoxicity Program and recently served as Co-Investigator on a U.S. Army study of neurotoxicity. He has served as an NIH Study Section Member in Cell Injury and Repair in Neurodegeneration, and as an NIH Study Section ad hoc Reviewer for Neurodegeneration and Glia in Disease.
Positions & HonorsPositions
|2004-present||Secondary Appointment, Assistant Professor, Division of Biokinesiology and Physical Therapy, University of Southern California|
|1999-present||Assistant Professor, Department of Neurology, and Department of Cell and Neurobiology, University of Southern California|
|1995-1999||Research Scientist, The Parkinson's Institute, Sunnyvale, CA|
|1994-1995||Senior Postdoctoral Research Fellow, Department of Neurology, Columbia University, NY|
|1993-1995||Course Coordinator, Biochemistry and Physiology Course, Yale Physicians Assoc. Program, New Haven, CT|
|1992-1994||Postdoctoral Research Fellow, Department of Neurology, Yale University, New Haven, CT|
Selected Honors & Awards
|2005-2006||National Institutes of Health Study Section ad hoc Reviewer, Neurodegeneration and Glia in Disease|
|2004, 2006, 2008||Meeting Co-Organizer with G. Petzinger (USC) and B. Teter (UCLA), Plasticity and Repair in Neurodegenerative Disorders, Second Workshop, UCLA Conference Center, Lake Arrowhead, CA|
|2003-present||National Institutes of Health Study Section Member, Cell Injury and Repair in Neurodegeneration|
|2001-2006||United States Army Parkinson's and Neurotoxicity Program, ad hoc reviewer|
|1999-2004||United States Army Parkinson's and Neurotoxicity Program|
|Columbia University, NY||Postdoc||1995||Neurology|
|Yale University, CT||Postdoc||1992||Neurology|
|Yale University, CT||Postdoc||1990||Molecular Biophysics|
|University of Southern California||Ph.D.||1990||Molecular Biology|
|University of California, Davis||M.Sc.||1984||Genetics|
|University of Toronto, Ontario||B.Sc.||1982||Microbiology/Biochemistry|
- Akopian, G., Crawford, C., Beal, M. F., Cappelletti, M., Jakowec, M. W., Petzinger, G. M., Zheng, L., Gheorghe, S. L., Reichel, C. M., Chow, R., and Walsh, J.P. (2008) Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia. J. Neurosci. 28(38): 9585-97.
- Vucković, M.G., Wood, R.I., Holschneider, D.P., Abernathy, A., Togasaki, D.M., Smith, A., Petzinger, G.M., and Jakowec, M.W. (2008) Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. Neurobiol Dis. 32(2): 319-27.
- Fisher, B.E., Wu, A.D., Salem, G.J., Song, J., Lin, C.H., Yip, J., Cen, S., Gordon, J., Jakowec, M., and Petzinger, G. (2008) The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease. Arch Phys Med Rehabil 89(7): 1221-9.
- Petzinger, G. M., J. Walsh, G. Akopian, E. Hogg, A. Abernathy, P. Arevalo, P. Turnquist, B. E. Fisher, D. Togasaki, and M. W. Jakowec (2007) Effects of Treadmill Exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-(MPTP)-Lesioned Mouse Model of basal ganglia injury. J. Neurosci. B (20) 5291-5300.
- Lund, B. T., Y. Chakryan, N. Ashikian, L. Mnatsakanyan, C. J. Bevan, R. Aguilera, T. Gallaher, and M. W. Jakowec (2006) Association of MBP peptides with Hsp70 in normal appearing human white matter. J. Neurological Sci. 249 (2):122-34.
- Petzinger, G.M., K. Nixon, B. E. Fisher, A. Abernathy, and M. W. Jakowec. (2006) Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. J. Neurosci. Res. 83 (2) 332-347.
- Hughes-Davis, E. J., J. P. Cogen, M. W. Jakowec, H. W. Cheng, G. Grenningloh, C. K. Meshul, and T. H. McNeill. (2005) Differential regulation of the growth-associated proteins GAP-43 and superior cervical ganglion-10 in response to lesions of the cortex and substantia nigra in the adult rat. Neuroscience. 134 (4) 1231-12139.
- Shakil, S. S., H. K. Homer, C. Moore, A. T. Abernathy, M. W. Jakowec, G. M. Petzinger, and C. K. Meshul (2005) High and low responders to novelty show differential effects in striatal glutamate. Synapse 58 (3) 200-207.
- Petzinger, G.M., K. Nixon, B. E. Fisher, A. Abernathy, and M. W. Jakowec. (2005) Behavioral Recovery in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-lesioned Squirrel Monkey (Saimiri sciureus): Analysis of Striatal Dopamine and the Expression of Tyrosine Hydroxylase and Dopamine Transporter Proteins. J. Neurosci. Res. 83 (2) 332-347.
- Jakowec, M.W., and G.M. Petzinger (2004) The MPTP-Lesioned Model of Parkinson's Disease with Emphasis on Mice and Nonhuman Primates. Comparative Medicine 54 (5) 497-513.
- Fisher, B.E., G. M. Petzinger, K. Nixon, E. Hogg, S. Bremmer, C. K. Meshul, and M. W. Jakowec. (2004) Exercise-Induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1, 2, 3,6-tetrahydropyridine-lesioned mouse basal ganglia. Journal Neuroscience Research 77: 378-390.
- Jakowec M.W., K. Nixon, E. Hogg, T. McNeill, and G. M. Petzinger. (2004) Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. J. Neurosci. Res. 76 (4) 539-550.