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Michael Jakowec

Dr. Michael Jakowec, PhD, is Assistant Professor of Neurology and Biokinesiology & Physical Therapy at USC. He has been a member and ad hoc reviewer for the U.S. Army Parkinson's and Neurotoxicity Program and recently served as Co-Investigator on a U.S. Army study of neurotoxicity. He has served as an NIH Study Section Member in Cell Injury and Repair in Neurodegeneration, and as an NIH Study Section ad hoc Reviewer for Neurodegeneration and Glia in Disease.

Positions & Honors

Positions
2004-present Secondary Appointment, Assistant Professor, Division of Biokinesiology and Physical Therapy, University of Southern California
1999-present Assistant Professor, Department of Neurology, and Department of Cell and Neurobiology, University of Southern California
1995-1999 Research Scientist, The Parkinson's Institute, Sunnyvale, CA
1994-1995 Senior Postdoctoral Research Fellow, Department of Neurology, Columbia University, NY
1993-1995 Course Coordinator, Biochemistry and Physiology Course, Yale Physicians Assoc. Program, New Haven, CT
1992-1994 Postdoctoral Research Fellow, Department of Neurology, Yale University, New Haven, CT

Selected Honors & Awards
2005-2006 National Institutes of Health Study Section ad hoc Reviewer, Neurodegeneration and Glia in Disease
2004, 2006, 2008 Meeting Co-Organizer with G. Petzinger (USC) and B. Teter (UCLA), Plasticity and Repair in Neurodegenerative Disorders, Second Workshop, UCLA Conference Center, Lake Arrowhead, CA
2003-present National Institutes of Health Study Section Member, Cell Injury and Repair in Neurodegeneration
2001-2006 United States Army Parkinson's and Neurotoxicity Program, ad hoc reviewer
1999-2004 United States Army Parkinson's and Neurotoxicity Program

Education

Columbia University, NY Postdoc 1995 Neurology
Yale University, CT Postdoc 1992 Neurology
Yale University, CT Postdoc 1990 Molecular Biophysics
University of Southern California Ph.D. 1990 Molecular Biology
University of California, Davis M.Sc. 1984 Genetics
University of Toronto, Ontario B.Sc. 1982 Microbiology/Biochemistry

Selected Publications

  1. Akopian, G., Crawford, C., Beal, M. F., Cappelletti, M., Jakowec, M. W., Petzinger, G. M., Zheng, L., Gheorghe, S. L., Reichel, C. M., Chow, R., and Walsh, J.P. (2008) Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia. J. Neurosci. 28(38): 9585-97.
  2. Vucković, M.G., Wood, R.I., Holschneider, D.P., Abernathy, A., Togasaki, D.M., Smith, A., Petzinger, G.M., and Jakowec, M.W. (2008) Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. Neurobiol Dis. 32(2): 319-27.
  3. Fisher, B.E., Wu, A.D., Salem, G.J., Song, J., Lin, C.H., Yip, J., Cen, S., Gordon, J., Jakowec, M., and Petzinger, G. (2008) The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease. Arch Phys Med Rehabil 89(7): 1221-9.
  4. Petzinger, G. M., J. Walsh, G. Akopian, E. Hogg, A. Abernathy, P. Arevalo, P. Turnquist, B. E. Fisher, D. Togasaki, and M. W. Jakowec (2007) Effects of Treadmill Exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-(MPTP)-Lesioned Mouse Model of basal ganglia injury. J. Neurosci. B (20) 5291-5300.
  5. Lund, B. T., Y. Chakryan, N. Ashikian, L. Mnatsakanyan, C. J. Bevan, R. Aguilera, T. Gallaher, and M. W. Jakowec (2006) Association of MBP peptides with Hsp70 in normal appearing human white matter. J. Neurological Sci. 249 (2):122-34.
  6. Petzinger, G.M., K. Nixon, B. E. Fisher, A. Abernathy, and M. W. Jakowec. (2006) Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. J. Neurosci. Res. 83 (2) 332-347.
  7. Hughes-Davis, E. J., J. P. Cogen, M. W. Jakowec, H. W. Cheng, G. Grenningloh, C. K. Meshul, and T. H. McNeill. (2005) Differential regulation of the growth-associated proteins GAP-43 and superior cervical ganglion-10 in response to lesions of the cortex and substantia nigra in the adult rat. Neuroscience. 134 (4) 1231-12139.
  8. Shakil, S. S., H. K. Homer, C. Moore, A. T. Abernathy, M. W. Jakowec, G. M. Petzinger, and C. K. Meshul (2005) High and low responders to novelty show differential effects in striatal glutamate. Synapse 58 (3) 200-207.
  9. Petzinger, G.M., K. Nixon, B. E. Fisher, A. Abernathy, and M. W. Jakowec. (2005) Behavioral Recovery in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-lesioned Squirrel Monkey (Saimiri sciureus): Analysis of Striatal Dopamine and the Expression of Tyrosine Hydroxylase and Dopamine Transporter Proteins. J. Neurosci. Res. 83 (2) 332-347.
  10. Jakowec, M.W., and G.M. Petzinger (2004) The MPTP-Lesioned Model of Parkinson's Disease with Emphasis on Mice and Nonhuman Primates. Comparative Medicine 54 (5) 497-513.
  11. Fisher, B.E., G. M. Petzinger, K. Nixon, E. Hogg, S. Bremmer, C. K. Meshul, and M. W. Jakowec. (2004) Exercise-Induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1, 2, 3,6-tetrahydropyridine-lesioned mouse basal ganglia. Journal Neuroscience Research 77: 378-390.
  12. Jakowec M.W., K. Nixon, E. Hogg, T. McNeill, and G. M. Petzinger. (2004) Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. J. Neurosci. Res. 76 (4) 539-550.