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Steven Finkel
Associate Professor of Biological Sciences
Contact Information
Office: MCB RRI 319B
Phone: (213)821-1498
E-mail:
sfinkel@usc.edu
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Education
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 B.A. Molecular Biology, University of California, Berkeley, 5/1987
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Ph.D. Biological Chemistry, University of California, Los Angeles, 7/1994
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Postdoctoral Training
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Postdoctoral Research Fellow, Harvard Medical School, 1994-1999
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Academic Appointment, Affiliation, and Employment History
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Postdoctoral Research Fellow, Harvard Medical School, 10/01/1994-12/31/1999
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Description of Research
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Summary Statement of Research Interests
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Professor Finkel researches three general areas: (1) understanding mechanisms of long-term survival and evolution in bacteria; (2) the generation of bacterial diversity in different environments; and (3) the role of DNA-protein interactions in controlling gene expression, organizing the chromosome, and protecting DNA during the stationary phase of the bacterial lifecycle. Currently, Finkel studies the evolution of the GASP (Growth Advantage in Stationary Phase) phenomenon under different conditions of stress and in bacterial mutants lacking certain DNA-damage repair proteins; characterizing the "DNA Eating" ability of E. coli during long-term survival and searching for evidence of natural competence and transformation; and characterizing the members of the Dps regulon, their roles in stationary phase survival and the mechanism of Dps-mediated chromatin organization.
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Research Specialties
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Aging and Development Biology, Ecology, Behavior & Evolution, Genetics
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Affiliations with Research Centers, Labs, and Other Institutions
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Alzheimer's Disease Research Center,http://www.usc.edu/dept/gero/ADRC/
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Center for Excellence in Genomic Science,http://www-hto.usc.edu/index.html
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Center of Excellence in Genomic Science,http://cegs.cmb.usc.edu/
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USC/Norris Comprehensive Cancer Center,http://ccnt.usc.edu
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Publications
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Book Chapter
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Finkel, S. E., Zinser, E., Kolter, R.
(2000).
Long-term survival and evolution in stationary phase. pp. p. 231-238. Bacterial Stress Responses/ASM.
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Journal Article
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Ren, C., Webster, P., Finkel, S. E., Tower, J.
(2007).
Increased internal and external bacterial load during Drosophila aging without life span trade-off. Cell Metabolism.
Vol. 6, pp. 144-152.
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Skvortsov, D., Abdueva, D., Stitzer, M. E., Finkel, S. E., Tavaré, S.
(2007).
Using expression arrays for copy number detection: an example from E. coli. BMC Bioinformatics.
Vol. 8, pp. 203.
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Stevens, M. H., Sanchez, M., Lee, J., Finkel, S. E.
(2007).
The role of total population size in the emergence and dynamics of diversification along a resource gradient in a homogeneous environment. Genetics.
Vol. in press
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Pepper, E. D., Farrell, M. J., Finkel, S. E.
(2006).
Role of penicillin binding protein 1b in competitive stationary phase survival and antibiotic resistance. FEMS Microbiology Letters.
Vol. 263, pp. 61-67.
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Finkel, S. E.
(2006).
Long-term survival during stationary phase: Evolution and the GASP phenotype. Nature Reviews Microbiology.
Vol. 4, pp. 113-120.
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Finkel, S. E., Petrie, A., Erbe, J.
(2005).
Use of long-term E. coli cultures to study generation of genetic diversity and teach general microbiology laboratory skills. American Biology Teacher. pp. p.87-92.
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Nair, S., Finkel, S. E.
(2004).
Dps protects cells against multiple stresses during stationary phase. Journal of Bacteriology/ASM.
Vol. 186, pp. 4192-4198.
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Farrell, M. J., Finkel, S. E.
(2003).
The growth advantage in stationary phase phenotype conferred by rpoS mutations is dependent on pH and nutrient source. Journal of Bacteriology/ASM.
Vol. 185, pp. 7044-7052.
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Yeiser, B., Pepper, E. D., Goodman, M. F., Finkel, S. E.
(2002).
SOS-induced DNA polymerases enhance long-term survival and evolutionary fitness. Proc. Natl. Acad. Sci. USA.
Vol. 99, pp. 8737-8741.
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Finkel, S. E., Kolter, R.
(1999).
Evolution of microbial diversity during prolonged starvation. Proc. Natl. Acad. Sci. USA.
Vol. 96, pp. 4023-4027.
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Honors and Awards
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NIH/NSF Career Development Award, NSF Faculty Early Career Award, 2003-2008
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Visiting Scholar Award, Alberta Heritage Foundation for Research, 2004-2005
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Service to the Profession
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Editorships and Editorial Boards
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Editorial Board, Applied and Environmental Microbiology, 2008-2010
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Editor, Biochemical Journal, 2006-2009
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Section Editor, EcoSal: Escherichia coli and Salmonella Cellular & Molecular Biology, 2003-2008
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Professional Memberships
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American Society for Microbiology, 1987-2006
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