Helena Chui, PhD
Professor and Chair, Department of Neurology
Raymond and Betty Mccarron Chair in Neurology

(323) 442-7686
(323) 442-3015
Email: chui(at)usc.edu 
Office: HCC 643 
Dept. Mailing Address: Department of Neurology
Keck School of Medicine, HCC 643
University of Southern California
Los Angeles, California 90033

BA 1974 The Johns Hopkins University, Baltimore, Maryland B.A.
MD 1977 The Johns Hopkins University, School of Medicine, Baltimore, Maryland M.D.

Postdoctoral Research Fellowship:
1978 - 1978 Division of Behavioral Neurology, University of Iowa, College of Medicine, Iowa City, Iowa

Started at USC: 1982

Research Topics: Alzheimer's disease (AD), vascular dementia, Parkinson's disease, epidemiology of stroke and AD

Research Description

Dr. Chui's research focuses on brain-behavior correlations in dementia. Her research has examined clinical heterogeneity, natural history, clinical diagnosis, and clinical-pathologic correlations in Alzheimer Disease (AD) and vascular dementia. She is Director of the Alzheimer’s Research Center and has evaluated over 1400 patients at the Alzheimer Disease Diagnostic and Treatment Center since 1985. Clinical data from these patients have been entered into a clinical database and over 200 of these cases have come to autopsy for detailed neuropathologic assessment. The individual research project headed by Dr. Chui examines the pathophysiologic and functional significance of deep white matter changes and pathological correlates of ischemic lesions visualized by MRI. The overreaching goal of Dr. Chui’s work is to: 1) provide state-of-the-art clinical diagnosis and treatment for patients with dementia, 2) provide education to health professionals, caregivers, and the community, and 3) translate research findings into practice.

Role in ISNSR:

Dr. Chui is a Co-Investigator on Project 1 and oversees MRI patient safety, clinical lesion identification and physician screens for patient participation.

Selected Publications

Mungas D, Reed BR, Jagust WJ, DeCarli C, Mack WJ, Kramer JH, Weiner MW, Schuff N, Chui HC. Volumetric MRI predictors of cognitive decline related to Alzheimer’s disease and cerebrovascular disease. Neurology 2002; 59: 867-873.

Hsu YY, Schuff N, Amend DL, Du AT, Norman D, Chui HC, Jagust WJ, Weiner MW (2002). Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunes. 2002; Alzheimer Dis Assoc Disord 16: 58-64

Zarow C, Mortimer JA, Chui HC. Neuronal loss is greater in the locus cŌruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson disease. Arch Neurology 2003;60:337-341.

Du AT, Schuff N, Zhu XP, Jagust WJ, Miller BL, Reed BR, Kramer JH, Mungas D, Yaffe K, Chui HC, Weiner MW. Atrophy rates of entorhinal cortex in AD and normal aging. Neurology 2003, 60:481-486.

Cardenas VA, Du AT, Hardin D, Ezekiel F, Weber P, Jagust WJ, Chui HC, Schuff N, Weiner MW. Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia. Neurobiol Aging 2003, 24:537-544.

Mungas D, Harvey D, Reed BR, Jagust WJ, DeCarli C, Beckett L, Mack WJ, Kramer JH, Weiner MW, Schuff N, Chui HC. Longitudinal volumetric MRI change and rate of cognitive decline. Neurology. 2005,65:565-71.

The Center is funded as part of the National Institutes of Health Roadmap Initiative, grant number P20 RR20700-01. NIH Program Administrator: Dr. Greg Faber