STUDY 1: Neurorehabilitation Therapeutics in Stroke Patients(Winstein and Chui)
This study will use fMRI and MRI to examine the relationship between severity and location of the initial lesion and functional changes in brain activities patterns following task specific training in stroke patients. The goal of this project is to demonstrate the feasibility of various training interventions that have been developed through collaborative efforts with the three interdisciplinary groups (i.e., bioinformatics/computer science; biological/behavioral science; and engineering/behavioral science) and informed by the principles associated with the learning of skilled actions. Study 1 represents the human clinical test-bed for the development of new directions in stroke neurorehabilitation encompassed by this Exploratory Center for Interdisciplinary Research. A corollary aim of Study 1 is to characterize the training-induced functional brain activation changes using our repeated measures fMRI design through three hand dexterity tasks—power grasp, precision grasp, and sequential finger tapping. We expect that the modulatory effects of our behavioral interventions will vary as a function of lesion locations and size, timing (acute, chronic), and motivation.
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The Center is funded as part of the National Institutes of Health Roadmap Initiative, grant number P20 RR20700-01. NIH Program Administrator: Dr. Greg Faber