Research is a very active and important part of our colorectal program. Clinical research is ongoing at all times. This is stimulated by interesting patients with complex problems where the management issues are unclear.

Students and residents are actively encouraged to participate in these projects. Funding is available to support those wishing to take a period of time to dedicate to a clinical project, and support for meeting travel and presentation is also available.

More basic research, however, is carried out on a number of levels.

Anorectal Physiology

Anal physiology is an area of clinical interest. We have an active anal physiology laboratory and testing facilities. This includes anal manometry, pudendal nerve terminal latency studies, and anal ultrasound. Clinical correlations are made, and basic observations of anorectal interaction and function have been reported from this laboratory. Residents are encouraged to participate in this area, and four fellows are usually committed to this activity on an annual basis.

Laparoscopy

Our Colorectal Department has had an active interest in laparoscopic colon resection. It has previously been the headquarters for the national colon and laparoscopic registry and is an active participant in the national randomized respective study. Laboratory investigations have looked at the physiology of laparoscopy and pneumoperitoneum and have attempted to define at a hormonal and molecular level the definition of laparoscopic colon resection. Current research looks at the impact of laparoscopic colon surgery on heat shock proteins in the rat model. This project is coordinated by Dr. Beart. For further information, please contact Dr. Beart or visit the National Cancer Institute Laparoscopic Colectomy for Colon Cancer Trial.

Gene Therapy for Colon Cancer

The University of Southern California has the most active and well- recognized gene therapy program in the United States. This program has developed several unique therapies and vector models.

The interests of the Colorectal Department are not in the treatment of colon cancer but in the prevention of colon cancer. Active research has been ongoing for more than two years into the prevention of colon cancer through the use of gene therapy. Research activity is active, funding is available, and we encourage participation and interest in this new and exciting field. For further information, please contact Dr. Beart.