Basic and clinical research remains a major focus of the
Division’s interests and activities. A number of investigators
are studying pulmonary structure and function at the organ,
tissue, cellular and molecular levels. Current areas of investigation
include: study of mechanisms and regulation of water, solute
and macromolecule transport across the pulmonary alveolar
epithelium; development of cell-type specific markers for
alveolar type I and type II cells using monoclonal antibodies
and genetic markers; and regulation of lung cell growth, differentiation
and gene expression in vitro. In addition, clinical research
studies in the fields of sarcoidosis and other granulomatous
disorders, acquired immune deficiency syndrome (AIDS), asthma,
septic shock, barotraumas, pulmonary edema, acute respiratory
distress syndrome (ARDS and Tuberculosis) and lung transplantation
are underway.
During the research experience, each fellow works closely
with a mentor who guides the trainee through the development
of a laboratory based or clinical research project. Formal
training in laboratory methodology, clinical research, epidemiology,
biostatistics, and ethics is available during research training
Clinical Research by Faculty
Asthma
Richard G. Barbers, M.D.
Mechanisms of Remodeling in Near-Fatal Asthma
Mechanisms of Remodeling in Pulmonary Fibrosis
Novel Therapeutic Interventions for BOS in Lung Transplant
Recipients
Novel Therapeutic Interventions in Severe Asthma
COPD
C. Thomas Boylen, M.D.
Oxygen Therapy in COPD
Immunological Diseases of the Lung
Pleural Diseases
Clubbing and Its Evaluation in an Asbestos Contact Population
Nocturnal Oxygen Therapy Trial
Acute Effects of Welding
Effects of Formaldehyde Exposure
Albert H. Niden, M.D.
Pathogenesis, Diagnostic Techniques and Treatment of Diffuse
Interstitial Lung Disease
Cystic Fibrosis
Adupa P. Rao, M.D.
Pioglitazone
MPEX
Creon
Dry Powder TOBI
Pulmozyme
Atlus
Neuromuscular Disease/Pulmonary
Rehabilitation
Ahmet Baydur, M.D.
Respiratory Mechanics
Control of Ventilation
Neuromuscular Disorders
Acute Respiratory Distress Syndrome
Sarcoidosis
Sarcoidosis/Interstitial Lung
Diseases
Om P. Sharma, M.D.
Predictors of Survival in Patients with Sarcoidosis
Long Term Prognosis of Myocardial Sarcoidosis
Neurological Sarcoidosis
Hide Shigemitsu, M.D.
Interstitial Lung Disease
Pulmonary Hypertension in patients with Sarcoidosis
Interventional Pulmonary
Ching Fe Chang, M.D.
Pulmonary Hypertension
S. Ganesh, M.D.
Basic Research by Faculty
Edward D. Crandall, Ph.D., M.D.
Markers of Rat Alveolar Epithelial Cell Development and Differentiation
Regulation of Pulmonary Epithelial Cell Differentiation
Acute and Chronic Lung Injury and the Factors that Influence
Recovery
Transport Properties of Pulmonary Alveolar Epithelium
Cell Pathophysiology of Alveolar Epithelium
Nanoparticle Interactions with Lung
Zea Borok, M.D.
Alveolar Epithelial Cell Function and Differentiation
Modulation of Alveolar Epithelial Cell Phenotype and Recovery
Following Lung injury
Pulmonary Alveolar Epithelial Cell Homeostasis
Stem Cell Biology in Lung InjuryTransport Properties of Pulmonary
Alveolar epithelium
Kwang-Jin Kim, Ph.D.
Drug Delivery Through the Lung
Janice M. Liebler, M.D.
Cell-Based Treatment of Lung Diseases
Lung Epithelial Cell Biology
Lung Injury and Repair
Lung Transplantation
Richard L. Lubman, M.D.
Cell-Matrix Interactions by Human Embryonic Stem Cells
Cell-Matrix Interaction by Alveolar Epithelium in Repair of
Lung Injury
Regulation of Intracellular pH and CO2 Transport by Alveolar
Epithelium
Renli Qiao, M.D., Ph.D.
Mechanisms of Alveolar Homeostasis
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