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The Glioma Research Group is an alliance of USC laboratories dedicated to
developing treatments for primary Central Nervous System tumors. By combining
and sharing the expertise of specialists in cellular and molecular biology,
radiation and surgical treatment of gliomas, the Glioma Research Group is
a multidisciplinary unit uniquely suited to pursuing all avenues for treating
this devastating disease.
TRANSLATIONAL RESEARCH
FOR GLIOMA TREATMENT
Dr. Chen’s laboratory laboratory is focused on translational research
for malignant gliomas, We are currently working on combining signal transduction
modulation... (more)
Primary Investigator: Thomas
C. Chen, MD, PhD
CYTOKINE AND GROWTH FACTOR
REGULATION OF CNS ENDOTHELIAL CELLS
Dr. Hofman’s laboratory is focused on identifying the mechanisms by which
specific cytokines and growth factors regulate endothelial cell function
in the central nervous system. (more)
Primary Investigator: Florence
M. Hofman , PhD
ANTICANCER DRUG ACTION,
CELL CYCLE REGULATION, AND CELL DEATH PATHWAYS
Dr. Schönthal’s lab investigates how certain novel anticancer
drugs cause tumor growth inhibition and tumor death (apoptosis/necrosis)...
(more)
Primary Investigator: Axel
H. Schönthal, PhD
CELLULAR
AND MOLECULAR RADIOBIOLOGY
Dr. Hill's laboratory is concerned with the cellular and molecular basis
of damage produced by radiations of all types. (more)
Primary Investigator:
Colin Hill, PhD
MAMMALIAN
STRESS RESPONSE: BASIC CELL BIOLOGY AND CLINICAL APPLICATIONS
A major research focus of Dr. Lee's laboratory is to investigate the regulation
and function of two stress-inducible proteins GRP78/BiP and GRP94. (more)
Primary Investigator:
Amy S. Lee, PhD
CONTORTROSTATIN
(CN): A POTENT INHIBITOR OF GLIOMA PROGRESSION
CN is a homodimeric disintegrin which was isolated from southern copperhead
venom. CN has been shown to inhibit glioma invasion, growth and angiogenesis.
Recent progress in preparing a recombinant form of the protein takes this
protein one step closer to clinical trials. Work still to be done includes
examining suitable delivery systems for glioma, and determining pharmacokinetics
and toxicity of the protein. (more)
Primary Investigator:
Francis Markland, PhD
AGING
AND CELLULAR NEUROBIOLOGY
Dr. Finch's main interests are the genomic regulation of aging processes...
(more)
Primary Investigator:
Caleb E. Finch, PhD
TRATEGIES
AND VECTOR SYSTEMS FOR GENE THERAPY
Dr. Kasahara's research investigates the use of molecular therapeutics
and gene transfer vectors for the treatment of gliomas... (more)
Primary Investigator: Noriyuki
Kasahara, MD, PhD.
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