The Division of Maternal Fetal Medicine is one of the leading research and practice groups in the country. Many of the most widely accepted protocols for fetal and maternal care throughout the country originated at USC. From its teaching and research base at Women's and Children's Hospital, the division has expanded to nine other sites in Los Angeles, Hollywood, Pasadena, Glendale, Burbank, Whittier and Santa Clarita.

Recently, the division has combined with the staff of Children's Hospital Los Angeles to develop a joint center for prenatal diagnosis and maternal and fetal care, The Institute for Maternal Fetal Health. All of the sites offer prenatal diagnosis and consultation. Complete obstetric care is offered at California Hospital Medical Center and at Hollywood Presbyterian Medical Center, adjacent to CHLA.