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In addition to the finest of patient care, a primary focus for the surgeons of the Thoracic and Foregut Division is advancement of their field. Consequently, research and development of new concepts, procedures, and insights into disease processes is an important aspect of the function of the Thoracic and Foregut team. A major focus of research is gastroesophageal reflux disease and its important complications: Barrett's esophagus and Barrett's associated adenocarcinoma. Research by the Thoracic and Foregut Division extends from patient based outcome analysis down to the level of molecular biology and examining the genes that may be responsible for the production of cancer. Vast experience with reflux disease, Barrett's esophagus, and cancer of the esophagus has given the surgeons of the Thoracic and Foregut Division the insight into these disease processes necessary to allow tailoring of therapy to the individual patient. For example, novel, state of the art techniques allow assessment of a patient's tumor for sensitivity to specific chemotherapy agents. With these and other techniques patients most likely to benefit from chemotherapy can be identified, and the best chemotherapy agents for that patient's tumor can be determined. By focusing research efforts on important clinical questions, benefits from the latest laboratory investigations are immediately transferable to the clinical setting. Consequently, patients treated by surgeons in the USC Thoracic and Foregut Division often receive treatment available no place else in the country or the world.
Other areas of focused research include swallowing disorders and cricopharyngeal dysfunction; the best surgical approaches and procedures for patients with reflux disease and esophageal cancer; quality of life in patients with reflux disease, Barrett's esophagus and esophageal cancer; the role of the diaphragm and hiatal hernia in precipitating and worsening reflux disease; the influence of luminal contents such as bile on the development of Barrett's esophagus and dysplasia; the implications of intestinal metaplasia within the esophagus, gastroesophageal junction, and stomach; the extent of surgical resection necessary to appropriately treat various stages of esophageal cancer; the relationship between reflux disease and airway disorders; optimal management of pleural disorders; minimally invasive treatment of pleural and thoracic diseases; the molecular biology of lung cancer; and optimal management of benign and malignant tracheal lesions. The bibliography of the Thoracic and Foregut Division demonstrates that advancing the fields of thoracic and foregut surgery is more than just rhetoric on their part, but instead represents a commitment equal to that demonstrated in their care of the individual patient.
Thoracic and Foregut Surgery Group Bibliography
1. DeMeester, S. R. and DeMeester, T. R. The diagnosis and management of Barrett's esophagus. [Review] [93 refs]. Adv Surg 33:29-68. 99.
2. Fuller, L., Huprich, J. E., Theisen, J., Hagen, J. A., Crookes, P. F., Demeester, S. R., Bremner, C. G., Demeester, T. R., and Peters, J. H. Abnormal esophageal body function: radiographic-manometric correlation. Am Surg 65(10), 911-4. 99.
3. Nigro, J. J., Hagen, J. A., DeMeester, T. R., DeMeester, S. R., Theisen, J., Peters, J. H., and Kiyabu, M. Occult esophageal adenocarcinoma: extent of disease and implications for effective therapy. Ann Surg 230(3), 433-8; discussion 438-40. 99.
4. Campos, G. M., Peters, J. H., DeMeester, T. R., Oberg, S., Crookes, P. F., and Mason, R. J. The pattern of esophageal acid exposure in gastroesophageal reflux disease influences the severity of the disease. Arch Surg 134(8), 882-7; discussion 887-8. 99.
5. Tomonaga, T., Houghton, S. G., Filipi, C. J., Hinder, R. A., Hunter, J., Dallemagne, B., Katkhouda, N., Kozarek, R., DeMeester, T. R., Deeik, R., Shiino, Y., Awad, Z. T., and Marsh, R. E. A new form of access for endo-organ surgery. The initial experience with percutaneous endoscopic gastrostomy. Surg Endosc 13(8), 738-41. 99.
6. Oberg, S., Peters, J. H., Nigro, J. J., Theisen, J., Hagen, J. A., DeMeester, S. R., Bremner, C. G., and DeMeester, T. R. Helicobacter pylori is not associated with the manifestations of gastroesophageal reflux disease. Arch Surg 134(7), 722-6. 99.
7. Gastal, O. L., Hagen, J. A., Peters, J. H., Campos, G. M., Hashemi, M., Theisen, J., Bremner, C. G., and DeMeester, T. R. Short esophagus: analysis of predictors and clinical implications. Arch Surg 134(6), 633-6; discussion 637-8. 99.
8. Mason, R. J. and DeMeester, T. R. Importance of duodenogastric reflux in the surgical outpatient practice. Hepatogastroenterology 46(25), 48-53. 99.
9. DeMeester, T. R., Peters, J. H., Bremner, C. G., and Chandrasoma, P. Biology of gastroesophageal reflux disease: pathophysiology relating to medical and surgical treatment. [Review] [110 refs]. Annu Rev Med 50:469-506. 99.
10. Nigro, J. J., DeMeester, S. R., Hagen, J. A., DeMeester, T. R., Peters, J. H., Kiyabu, M., Campos, G. M., Oberg, S., Gastal, O., Crookes, P. F., and Bremner, C. G. Node status in transmural esophageal adenocarcinoma and outcome after en bloc esophagectomy. J Thorac Cardiovasc Surg 117(5), 960-8. 99.
11. Schneider, J. H., Peters, J. H., Kirkman, E., Bremner, C. G., and DeMeester, T. R. Are the motility abnormalities of achalasia reversible? An experimental outflow obstruction in the feline model. Surgery 125(5), 498-503. 99.
12. Oberg, S., DeMeester, T. R., Peters, J. H., Hagen, J. A., Nigro, J. J., DeMeester, S. R., Theisen, J., Campos, G. M., and Crookes, P. F. The extent of Barrett's esophagus depends on the status of the lower esophageal sphincter and the degree of esophageal acid exposure. J Thorac Cardiovasc Surg 117(3), 572-80. 99.
13. Bremner, C. G. and DeMeester, T. R. Endoscopic treatment of Zenker's diverticulum [editorial; comment]. [Review] [16 refs]. Gastrointest Endosc 49(1), 126-8. 99.
14. Nigro, J. J., Hagen, J. A., DeMeester, T. R., DeMeester, S. R., Peters, J. H., Oberg, S., Theisen, J., Kiyabu, M., Crookes, P. F., and Bremner, C. G. Prevalence and location of nodal metastases in distal esophageal adenocarcinoma confined to the wall: implications for therapy [see comments]. J Thorac Cardiovasc Surg 117(1), 16-23; discussion 23-5. 99.
15. Mason, R. J. and Bremner, C. G. Myotomy for pharyngeal swallowing disorders. [Review] [145 refs]. Adv Surg 33:375-411. 99.
16. Nafstad, P., Hagen, J. A., Oie, L., Magnus, P., and Jaakkola, J. J. Day care centers and respiratory health. Pediatrics 103(4 Pt 1), 753-8. 99.
17. Hashemi, M., Sillin, L. F., and Peters, J. H. Current concepts in the management of paraesophageal hiatal hernia [see comments]. [Review] [22 refs]. J Clin Gastroenterol 29(1), 8-13. 99.
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