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USC vascular surgery specialists focus not only on survival, but on continued quality of life. The USC vascular surgery program is built on excellence in patient treatment combined with advances in basic research. Advanced gene transfer techniques are being developed. Coordinating these efforts is Hong Yu, PhD. Hong Yu, PhD, Assistant Professor of Research, joined the USC faculty in 1996 after being trained in the USC Gene Therapy Laboratories headed by Dr. W. French Anderson, a pioneer of human gene therapy.
The research team is studying the genetic engineering of vascular bypass grafts. The project purpose is to improve the patency rate of prosthetic and autogenous bypass grafts. Through gene transfer, the cells on bypass grafts are being made to over express a thrombolytic enzyme that will prevent clot formation. The long term goal of the project is to use the implanted conduits as a drug delivery system to deliver a variety of therapeutic proteins/drugs into the circulation.
The research project is supported by American Heart Association, Pacific Vascular Foundation, May R. Wright Foundation, James Zumberge Fund, Bank of America-Giannini Foundation, Charles E. Culpeper Foundation.
Research Focuses on Gene Therapy »
Intimal Hyperplasia »
Gene Transfer »
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