Lon S. Schneider , MD, MS

Research Interests

Alzheimer's disease and dementia
Clinical Trials methodology
Late-life depression
Geriatric psychiatry
Neuropsychopharmacology

Clinical Interests

Alzheimer's disease
Geriatric psychiatry
Psychopharmacology
Forensic psychiatry
Mood disorders (depression & mania)

Degrees

University of Southern California School of Medicine, Los Angeles, MS, 1995
Hahnemann University Medical College, Philadelphia, MD, 1978

Internships

LAC+USC Medical Center, 1978 - 1979

Residencies

LAC+USC Medical Center: Chief Resident , 1979 - 1982

Fellowships

University of Southern California: Geriatric Psychiatry, 1982 - 1983

Board Certification

American Board of Psychiatry & Neurology (Psychiatry), 1984
American Board of Psychiatry and Neurology (Geriatric Psychiatry), 2001

Awards

Tsai Memorial Lecture. Los Angeles/Brentwood VA Medical Center
The Best Doctors in America (Woodward/White, Inc.) , 2009
First Annual Dorothy Kirsten French Memorial Lecture. The French Foundation for Alzheimer Research
The 327 Best Mental Health Experts. Good Housekeeping
11th and 21st Annual Research Awards, Los Angeles Alzheimer Association
Best Doctors in Los Angeles. Los Angeles Magazine
Senior Investigator Award, American Association for Geriatric Psychiatry
Senator Mark Hatfield Award for Clinical Research, Alzheimer Association, 2004
Jay L. Foster Memorial Lecture. University of Pittsburgh School of Public Health

Memberships

Distinguished Fellow,American Psychiatric Association
Fellow, Southern California Psychiatric Society
American Association for Geriatric Psychiatry
American College of Neuropsychopharmacology
American Geriatrics Society
American Society of Clinical Psychopharmacology
American Society of Experimental NeuroTherapeutics
International College of Geriatric Psychoneuropharmacology
International Psychogeriatric Association
Society of Biological Psychiatry
West Coast College of Biological Psychiatry

Clinical Affiliation

USC Care Medical Group, Inc.
USC University Hospital

Selected Publications

Schneider LS, Pollock VE, Lyness SA. A metaanalysis of controlled trials of neuroleptic treatment of dementia. Journal of the American Geriatrics Society 38: 553-563, 1990.

Schneider LS, Farlow MR. Predicting response to cholinesterase inhibitors in Alzheimer's disease: possible approaches. CNS Drugs 4(2);114-124, 1995.

Schneider LS, Farlow MR, Henderson VW, Pogoda JM. Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer's disease. Neurology 46:1580-1584, 1996.

Schneider LS, Small GW, Hamilton SH, et al. Estrogen replacement and response to fluoxetine in a multicenter geriatric depression trial. American Journal of Geriatric Psychiatry 5:97-106, 1997.

Schneider LS, Olin JT, Doody RS, et al. Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change. Alzheimer's Disease and Associated Disorders 11(suppl 2):S22-S32, 1997.

Tariot PN, Schneider LS, Mintzer JE, et al. Safety and tolerability of divalproex sodium in the treatment of signs and symptoms of mania associated with dementia: results of a double-blind, placebo-controlled trial. Current Therapeutic Research 62(1): 51-67, 2001.

Schneider LS, Olin JT, Lyness SA, Chui HC. Eligibility of Alzheimer's disease clinic patients for clinical trials. Journal of the American Geriatrics Society 45(8):923-928, 1997

Schneider LS. Cholinergic deficiency in Alzheimer's disease: a pathogenic model. American Journal of Geriatric Psychiatry 6:S49-S55, 1998.

Schneider LS, Tariot PN, Lyketsos CG, et al. National Institute of Mental Health - Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer

Schneider LS, Small G, and Clary CM. Estrogen replacement therapy and antidepressant response to sertraline on older depressed women. American Journal of Geriatric Psychiatry 9(4): 393-399, 2001.

Olin JT, Schneider LS, Katz IR, et al. Provisional diagnostic criteria for depression of Alzheimer disease. American Journal of Geriatric Psychiatry 10(2):125-128, 2002.

Lahiri DK, Farlow MR, Sambamurti K, Greig NH, Giacobini E, Schneider LS. A critical analysis of new molecular targets and strategies for drug developments in Alzheimers disease. Current Drug Targets 4(2): 97-112, 2003.

Schneider LS, Nelson JC, Clary CM, et al. An 8- week, multicenter, parallel-group, double-blind, placebo-controlled study of sertraline in elderly outpatients with major depression. American Journal of Psychiatry, 160(7): 1277-1285, 2003.

Schneider LS, Dagerman KS. Psychosis of Alzheimers disease: clinical characteristics and history. Journal of Psychiatric Research, 38(1): 105-111, 2004.

Schneider LS. Estrogen and dementia - insights from the Womens Health Initiative Memory Study. Journal of the American Medical Association, 291(24): 3005-3007, 2004.

Schneider LS. Mild cognitive impairment. American Journal of Geriatric Psychiatry 13(8): 629-632, 2005.

Schneider LS, DeKosky ST, Farlow MR et al. A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer

Schneider LS, Dagerman KS, Insel, P. Risk of death with atypical antipsychotics treatment for dementia: meta-analysis of randomized placebo-controlled trials. Journal of the American Medical Association, 294(15): 1934-1943, 2005.

Schneider LS, Dagerman K, Insel PS. Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized placebo-controlled trials. American Journal of Geriatric Psychiatry, 14 (3): 191-210, 2006.

Schneider LS, Tariot PN, Dagerman KS, et al. Effectiveness of atypical antipsychotic drugs for patients with Alzheimers disease. New England Journal of Medicine, 355(15):1525-1538, 2006.

Schneider LS, Clark C, Doody R, et al. ADCS Prevention Instrument Project: ADCS-clinician

Nelson JC, Delucchi K, Schneider LS. Suicidal thinking and behavior during treatment with sertraline in late life depression. American Journal of Geriatric Psychiatry, 15(7): 573-580, 2007.

Rosenheck RA, Leslie DL, Sindelar J, Miller EA, Tariot PN, Dagerman KS, Davis S, Lebowitz BD, Rabins P, Hsiao JK, Lieberman JA, Schneider LS. A randomized trial of the cost-effectiveness of second generation antipsychotics and placebo in the treatment of psychosis and aggression in Alzheimer

Rabins PV, Blacker D, Rovner BW, Rummans T, Schneider LS, Tariot PN, Blass DM. Practice guidelines for the treatment of patients with Alzheimers disease and other dementias, Second Edition. Am J Psychiatry 2007; 164 (12 suppl): 5-56

Nelson JC, Delucchi K, Schneider LS. Efficacy of second generation antidepressants in late life depression: a meta-analysis of the evidence. American Journal of Geriatric Psychiatry 2008: 16: 558-567.

Schneider LS. Prevention therapeutics of dementia. Alzheimers & Dementia; 4(1): S122-S130, 2008.

Miller EA, Schneider LS, Zbrozek A, Rosenheck RA. Sociodemographic and clinical correlates of utility scores in Alzheimers disease. Value in Health 2008; 11 (7); 1120-1130

Sultzer DL, Davis SM, Tariot PN, Dagerman KS, Lebowitz BD, Lyketsos CG, Rosenheck RA, Hsiao JK, Liberman JA, Schneider LS. Clinical symptom responses to atypical antipsychotic medications in Alzheimers disease: Phase 1 outcomes from the CATIE-AD effectiveness trial. American Journal of Psychiatry, 2008; 165; 844-854.

Aisen PS, Schneider LS, Sano M, et al. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. Journal of the American Medical Association, 2008; 300(15); 1774-1783

Miller EA, Schneider LS, Rosenheck RA. Assessing the relationship between health utilities, quality of life, and health services use in Alzheimers disease. International Journal of Geriatric Psychiatry 2008; 23: 1-10.

Schneider LS. Ginkgo biloba extract and preventing Alzheimer disease. Journal of the American Medical Association, 2008; 300(19); 2306-2308.

Schneider LS, Lahiri DK. The perils of Alzheimer drug development. Current Alzheimer Research 2009; (in press)

Schneider, LS, Raman R, Schmitt FA, et al.. Characteristics and performance of a modified version of the ADCS-CGIC CIBIC+ for mild cognitive impairment clinical trials. Alzheimers Disease and Associated Disorders, 2009; 23(): (in press)

Schneider LS. Psychopharmacology: antidementia drugs. In, Kaplan & Sadocks Comprehensive Textbook of Psychiatry / IX (vol 3). Edited by BJ Sadock and V Sadock. Lippincott, Williams and Wilkins, Baltimore, 2008 (in press)

Schneider LS. Issues in design and conductance of clinical trials for cognitive-enhancing drugs. In, Animal and Translational Models of Behavioural Disorders, volume 2: Neurological Disorders. Edited by RA McArthur and F Borsini. Elsevier, New York, 2008