Istvan Seri , M.D., Ph.D. Professor
Division Chief, USC Division of Neonatal Medicine
I was born in Hungary and received my MD and PhD degrees in Budapest from the Semmelweis School of Medicine and the Hungarian Academy of Sciences, respectively. Completed residency at the Department of Pediatrics in Budapest and joined the faculty at Semmelweis. I was then trained at the Karolinska Institute, Stockholm, Sweden and at Harvard Medical School, Boston, MA in developmental physiology, renal physiology and neonatology. After completing 4 fellowships, I joined the faculty at Harvard Medical School in 1991 and continued with my NIH-grant supported research as well as with clinical activities in Neonatology at the Brigham & WomenResearch Interests
I have been interested in the mechanisms of action of the cardiovascular, renal and neuroendocrine effects of dopamine in the preterm and term neonate and in the pathophysiology and treatment of neonatal shock. I have performed a host of clinical, translational and basic science studies over the past 25 years and described some of the mechanisms of the renal hemodynamic and direct tubular actions of dopamine. My studies have contributed to the discovery of the short-term regulation of the sodium/potassium-ATPase by dopamine. More recently, I have been focusing on measuring organ blood flow changes during neonatal shock and its treatment and on the treatment of pressor-resistant hypotension. Clinical Interests
Treatment of neonatal shock
Treatment of complex neonatal cases requiring a multidisciplinary approach
Degrees
Hungarian Academy of Sciences, PHD, 1985
Semmelweis University School of Medicine, MD, 1976
Internships
Semmelweis University School of Medicine, 1976 - 1977
Residencies
Semmelweis University School of Medicine, 1977 - 1979
Fellowships
St. Goran's Children's Hospital, Karolinska Institute, 1984 - 1985
Brigham & Women's Hospital, Harvard Medical School, 1986 - 1988
Beth Isreal Hospital, Brigham & Women's Hospital, 1989 - 1991
Board Certification
Hungarian Board of Pediatrics, 1981
American Board of Pediatrics, 1991
Specialty Board in Neonatal Perinatal Medicine, 1993
Awards
Semmelweis Awardee, Semmelweis University, Budapest, 1986
Charles A. Janeway Scholarship in Child Health Research, Harvard Medical School, 1991
75th Year Anniversary of the Hungarian Pediatric Society Award, 1999
Honorary member of the Hungarian Academy of Pediatrics, Budapest, 1999
The Pediatric Resident's Faculty Teaching Honor Roll, CHOP, 1999
Faculty Teacher of the Year, CHOP, 2000
Blockley-Osler Award for Excellence in Teaching Modern Clinical Medicine, CHOP, 2000
The Pediatric Resident's Faculty Teaching Honor Roll, CHOP, 2001
Neonatal Faculty Teaching Award, CHOP , 2001
Establishment of the Istvan Seri Faculty Teaching Award, CHOP, 2001
MEMBERSHIPS & AFFILIATIONS |
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Memberships
Eastern Society of Pediatric Research
California Association of Neonatologists
Academic Neonatologists of Southern California
Western Society of Pediatric Research
Kidney Council, American Heart Association
American Medical Association
American Academy of Pediatrics
American Association for the Advancement of Science
Society for Pediatric Research
European Society of Pediatric Research
World Council of Hungarian Professors
Clinical Affiliation
Women's & Children's Hospital
LAC+USC Medical Center
Childrens Hospital Los Angeles
Aperia A, Bertorello A, Seri I. Dopamine causes inhibition of Na+-K+-ATPase activity in proximal convoluted tubule segments. Am J Physiol 252(Renal Fluid Electrolyte Physiol. 21): F39-F45, 1987.
Seri I, Kone BC, Gullans SR, Aperia A, Brenner BM, Ballermann BJ. Influence of Na+ intake on the dopamine-induced inhibition of renal cortical Na+-K+-ATPase. Am J Physiol 258(Renal Fluid Electrolyte Physiol 27): F52-F60, 1990.
Seri I. Cardiovascular, renal and endocrine actions of dopamine in neonates and children. J Pediatr 126: 333-344, 1995.
Seri I, Abbasi S, Wood DC, and Gerdes JS. Regional hemodynamic effects of dopamine in the sick preterm infant. J Pediatr, 133: 728-34, 1998.
Seri I, Tan, R, Evans J. The effect of hydrocortisone on blood pressure in preterm neonates with pressor-resistant hypotension Pediatrics 107: 1070-4, 2001. More Publications>>
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