Duncan C. Thomas , PhD Professor
Co-Director, Biostatistics Division
Verna R. Richter Chair in Cancer Research Dr. Thomas is interested in the development of statistical methods in epidemiology, with special emphasis on cancer epidemiology and occupational and environmental health. He is conducting epidemiological research on radiation carcinogenesis, using data on fallout at the United States' Nevada test site, on Japanese A-bomb survivors, and on medical irradiation. He is also developing statistical methods for genetic epidemiology, especially for studies of the relationship of gene-environment interactions to diabetes, breast cancer, and other cancers. Research Interests
Development of statistical methods in epidemiology, with special emphasis on cancer epidemiology and occupational and environmental health
Statistical methods for genetic epidemiology.
Degrees
McGill University, PHD, 1976
Stanford University, MS, 1969
Professional Experience
Assistant Professor, Epidemiology and Health, McGill University., 1976 - 1982
Associate Professor, Epidemiology and Health, McGill University., 1982 - 1984
Associate Professor, Dept. of Preventive Medicine, University of Southern California., 1984 - 1988
MEMBERSHIPS & AFFILIATIONS |
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Memberships
International Genetic Epidemiology Society
Selected Publications Thomas DC. General relative risk models for failure time and matched case-control Studies. Biometrics 1981;37:673-686.
Thomas DC. Nonparametric estimation and tests of fit for dose-response relations. Biometrics 1983;37:263-268.
Thomas DC. Statistical methods for analyzing effects of temporal patterns of exposure in cancer risks. Scand J Work Environ Health 1983;11:248-253.
Thomas DC, McNeill KG, Dougherty C. Estimates of lifetime lung cancer risk resulting from radon daughter exposure. Health Phys 1985;49:825-846.
Thomas DC, Siemiatycki J, Dewar R, Robins J, Holdberg M, Armstrong BG. The problem of multiple inference in studies designed to generate hypotheses. Am J Epidemiology 1985;122:1080-1095.
Thomas DC, Siemiatycki J, Goldberg M, Dewar R. Methods for relating several diseases in case hetergeneity studies. Stat Med 1986;5:49-60.
Thomas DC. Pitfalls in the analysis exposure-time-response relationships. J Chron Dis 1987;40:2:71-78.
Thomas DC, Whittemore AS. Methods for testing interactions, with applications to occupational exposures, smoking and lung cancer. Am J Industr Med 1988;13:131-147.
Thomas DC. Exposure-time-response relationships with applications to cancer epidemiology. Ann Rev Pub Health 1988;9:451-482.
Thomas DC. A model for dose rate and duration of exposure effects in radiation carcinogenesis. Envirn Hlth Perspect 1990;87:163-172.
Thomas DC, Langholz B, Mack W, Floderus-Myrrhed B. Bivariate survival models for analysis of genetic and environmental effects in twins. Genet Epidemiol 1990;7:121-135.
Thomas DC. Fitting genetic data using Gibbs sampling: An application to nevus counts in 38 Utah kindreds. Cytogenet Cell Genet 1991;59:228-230.
Langholz B, Thomas DC. Efficiency of cohort sampling designs: Some surprising results. Biometrics 1991;7:1563-1571.
Thomas DC, Petitti D, Goldharber M, Swan S, Rappaport E, Hertz-Picciotto I. Reproductive outcomes in relation to malathion spraying in the San Francisco Bay Area 1981-82. Epidemiology 1992; 3: 32-40.
Thomas DC, Cortessis V. A Gibbs sampling approach to linkage analysis. Hum Hered 1992;42:781-794.
Thomas DC, Blettner M, Day NE. Use of external rates in nested case-control studies with applications to the international radiation study of cervical cancer patients. Biometrics 1992;48:781-794.
Thomas DC, Darby S, Fagnani F, Hubert P, Vaeth M, Weiss K. Measures of lifetime detriment from radiation exposure: Principles and methods. Health Phys 1992;63:259-272.
Thomas DC, Preston-Martin S. Risk of cancer causation by diagnostic x-rays. Health Phys 1992;63:576-578.
Thomas DC, Stram DO, Dwyer J. Exposure measurement error: Influence on exposure-correction. Ann disease relationships and methods of Rev Pub Health 1993; 14: 69-93.
Kerber R, Simon SL, Till JE, Lyon JL, Thomas DC, Preston-Martin S, Rallison ML, Lloyd RD, Stevens W. A cohort study of thyroid disease in relation to fallout from nuclear weapons testing. JAMA 1993; 270: 2076-82.
Thomas DC, Pogoda J, Langholz B, Mack W. Temporal factors modifying the radon-smoking interaction. Health Phys 1993;66:257-262.
Gauderman WJ, Thomas DC. Censored survival models for genetic epidemiology: A Gibbs sampling approach. Genet Epidemiol 1994;11:171-188.
London SJ, Bowman JD, Sobel E, Thomas DC, Garabrant DH, Pearce N, Bernstein L, Peters JM. Exposure to magnetic fields among electrical workers in relation to leukemia risk in Los Angeles County. Am J Indust Med 1994:26:47-60.
Bowman JD, Thomas DC, Peters J. Cancer risk from resonances with power-frequency magnetic fields: an hypothesis from calcium efflux and cyclotron resonance studies. Bioelectromagnetics 1995;16:48-59.
Gauderman WJ, Witte JS, Faucett CL, Morrison J, Thomas DC. Genetic epideminologic analysis of quantitative phenotypes using Gibbs sampling. Genet Epidemiol 1995;12:753-758.
Langholz B, Tuomilehto-Wolf E, Thomas D, Pitkaniemi J, Tuomilehto J, The DiMe Study Group. Variation in HLA-associated Risks of childhood insulin dependent diabetes in the Finnish population: I.Main effects at A, B and DR loci. Genet Epidemiol 1995;12:441-453.
Thomas D, Pitkaniemi J, Langholz B, Tuomilehto-Wolf E, Tuomilehto J, The DiMe Study Group. Variation in HLA-associated risks of childhood insulin depenent diabetes in the Finnish population II. Haplotype effects. Genet Epidemiol 1995;12:455-466.
Thomas DC, Gauderman J. Gibbs sampling methods in genetics. In: Gilks W, Richardson S, Spiegelhalter D (eds.), Markov Chain Monte Carlo in Practice. Chapman and Hall 1995:419-440.
Till JE, Simon SL, Kerber R, Lloyd D, Kerber RL, Thomas DC, Lyon JL, Preston-Martin S. The Utah thyroid cohort study: analysis of the dosimetry methodology and results. Health Physics 1995;68:472-478.
Simon SL, Till JE, Lloyd D, Kerber RL, Thomas DC, Preston-Martin S, Lyon JL, Stevens W. The Utah leukemia case-control study: dosimetry methodology and results. Health Physics 1995;68:460-471.
Faucett CL, Thomas DC. Simultaneously modeling censored survival data and repeatedly measured covariates using Gibbs sampling. Stat Med 1995:15:1663-1685.
Preston-Martin S, Navidi W, Bowman J, Thomas D. Los Angeles study of residential electromagnetic fields and childhood brain tumors. Am J Epidemiol 1996;143:105-119.
Gauderman WJ, Thomas DC. Analysis of gene-smoking interaction in lung cancer. Genet Epidemiol 1997;14:199-214.
Thomas DC, Richardson S, Gauderman J, Pitkaniemi J. A Bayesian approach to multipoint mapping in nuclear families. Genet Epidemiol 1997;14:903-908.
Thomas DC. New approaches to the analysis of cohort studies. Epidemiol Rev 1998;14:122-134.
Langholz B, Thomas D, Xiang A, Stram DO. Latency analysis in epidemiologic studies of occupational exposures: application to the Colorado plateau uranium miners cohort. Am J Indust Med 1999;35:246-256.
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