Florence M. Hofman , PhD

Research Interests

Dr. Hofman's field of expertise is angiogenesis and the blood-brain-barrier in human primary brain tumors and metastatic breast cancer to the brain. Her approach is to functionally characterize the tumor-associated brain endothelial cells because these cells are the target for anti-vascular therapy in cancer. Her laboratory uses both in vitro and in vivo systems to determine the mechanism(s) of chemoresistance. Once it is understood why these cells are resistant to standard of care drugs, they will identify agents which specifically disrupt the tumor vasculature, resulting in eliminating tumor growth.

Degrees

Weizmann Institute of Science, PhD, 1976
University of Wisconsin, MS, 1970

Board Certification

Certified Clinical Immunologist (American Board of Medical Laboratory Immunology), 1980

Memberships

American Association of Immunologists
Clinical Immunology Society
Society for Neuroscience
American Association for Cancer Research

Chen P, Shibata M, Zidovetzki R, Fisher M, Zlokovic B, Hofman, FM. Endothelin-1 Induced Production of Monocyte Chemoattractant Protein-1 by Human Brain-derived Endothelial Cells via Protein Kinase C-dependent Pathway. J. Neuroimmunol. 116:62-73, 2001.

Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nature Medicine. 9(7):907-13, 2003.

Charalambous C, Virrey J, Kardosh A, Jabbour MN, Qazi-Abdullah L, Zidovetzki R, Schnthal AH, Chen TC, Hofman FM. Glioma-associated endothelial cells show evidence of replicative senescence. Experimental Cell Research.

Kardosh A, Soriano N, Liu Y-T, Uddin J. Petasis NA, Hofman FM, Chen TC, Schnthal AH. Multi-target inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2-inhibitory analog of celecoxib. BLOOD 106(13):4330-8, 2005.

Milan J, Charalambous C, Chen TC, Li W, Guan S, Hofman FM, and Zidovetzki R. Multiple Parallel Signaling Pathways Involved in Endothelin-1-induced Brain Endothelial Cell Migration. Am. J. Physiology- Cell Physiology. 291(1):C155-64, 2006.

Charalambous C, Hofman FM, Chen TC. Comparison between glioblastoma-derived and normal human brain endothelial cells. J. Neurosurgery 102: 699-705, 2005.

Charalambous C, Pen LB, Su YS, Milan J, Chen TC, Hofman FM. Interleukin (IL-8) Differentially Regulates Migration of Tumor-associated and Normal Human Brain Endothelial Cells. Cancer Research. 65(22):10347-54, 2005.