Neil Kaplowitz , MD Professor of Medicine
Chief, Division of Gastrointestinal and Liver Diseases
USC Associates/Thomas H. Brem Chair in Medicine
Veronica P. Budnick Chair in Liver Disease Research Interests
My research interests are in mechanisms of liver cell death and the factors which influence the choice between nervous and apoptosis. This couples well with my clinical interest in pathogenisis, prevention and treatment of drug, toxin and alcohol induced liver injury. My second interest is in the membreane transport of glutathione in apual and borolateral membrane of the hepatoyl as well as brainmendothelial cells and lens epithelia. The former involves the charaitenyation of brown (oatp1, mrp2) and yet to be discovered GSH transporters and the latter involves the identification and charaitenyation of sodium glutathionl-transporters. The transport of glutathinol is pivotalin the interorgan homeostasis of glutathinol and cysteine. Clinical Interests
Diagnosis and treatment of liver diseases
Gastroenterology
Degrees
New York University, MD, 1967
Internships
Bellevue Hospital, N.Y., 1967 - 1968
Residencies
Bellevue Hospital, N.Y., 1968 - 1969
Albert Einstein Medical Ctr., New York, N.Y., 1969 - 1970
Rockefeller University Hospital, New York, N.Y., 1970 - 1971
Fellowships
Cornell University, New York Hospital - Gastroenterology , 1971 - 1972
Board Certification
American Board of Internal Medicine, 1975
Gastroenterology, 1975
MEMBERSHIPS & AFFILIATIONS |
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Memberships
AMERICAN FEDERATION FOR MEDICAL REDEARCH
Amercian Association for the Study of Liver Diseases
Western Society for Clinical Research
AMERICAN SOCIETY CLINICAL INVESTIGATION
AMERICAN ASSOCIATION PHYSICIANS
Clinical Affiliation
USC Care Medical Group
USC University Hospital
USC/Norris Cancer Hospital
Selected Publications Huang ZZ, Li H, Cai J, Kuhlenkamp J, Kaplowitz N, and Lu SC: Changes in gluthathoine homeostasis during liver regenration in the rat. Hepatology 27:147-153,1998
Fernandez-Checa J, Kaplowitz N, Garcia Ruiz C,Specify and sidedness of theoieher inhibition of the sinusdidal SDH transporter. AM J PHISOL 33:969-975,1996
Fernandez-Checa J, Kaplowitz N, Yi Y, Garcia Ruiz C, Knezic Z, Tahara S: Expression of rat liver GSH transport in Xenopus laevis oocytes. J Biol Chem, 268:2324-2328,1993
Fernandez-Checa J, Kaplowitz N, Takikawa H, Ookhtens M: Canalicular transport of Gsh in normal and EHBR mutant rats. J BIOL CHEM, 267:1667-1673,1992
Fernandez-Checa J, Kaplowitz N: The use of monochlorobimane to determine hepatic GSH levels and synehesis. ANAL BIOCHEM 190:212-219,1990
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