About the Core Facility

Mass spectrometry identifies proteins based upon the measured masses of a given protein's proteolytic fragments, usually a trypsin digest. The identification is done based on different algorithms which match observed experimental masses with theoretical peptide masses generated by in silico tryptic digestion of known proteins. The convergence of proteomics and genomics, wherein genome sequences of a great number of organisms are known, makes identification of most proteins possible.

The core's LCQ XP Plus with the Axima-CFR in the background.

Researchers may use the USC School of Pharmacy's Proteomic Core lab to assay their samples. Typically, samples are given to the lab for MS analysis as excised bands from polyacrylamide gels. The Proteomic Core will:

• Digest the samples
• Run appropriate MS and data analysis identification
• Return a report on the composition of the excised bands

Proteomic Core Facility
PSC 306B
1985 Zonal Avenue
Los Angeles, California 90033
(323) 442-1782 or (323) 442-1780