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Immunogenetics Expert Joins USC

12/15/05
Ian Hutchinson, whose work has involved diabetes, cystic fibrosis and infectious disease, has a joint appointment in the schools of pharmacy and medicine.
By Kukla Vera
Hutchinson's specialty is translating basic science concepts into applications in the clinical setting.

Immunogenetics and genomics specialist Ian Hutchinson has joined the USC School of Pharmacy, with a joint appointment in the Keck School of Medicine of USC as a professor of surgery.

Hutchinson also will serve as co-director of the Clinical Pharmacogenomics/Immunogenetics Laboratory in the USC School of Pharmacy.

Hutchinson has served as professor and chair of immunology at the University of Manchester, England since 1987. Internationally recognized as an expert in translational research, his specialty is translating basic science concepts into applications in the clinical setting. Most of his work has been in organ transplantation, but his previous studies have included immunogenetic aspects in oncology, diabetes, cystic fibrosis, cardiovascular disease and infectious disease.

“Ian Hutchinson is a world leader in developing applications of the Human Genome Project for understanding immunology and transplant immunology,” said Gilbert J. Burckart, professor and chair of the department of pharmacy. “In addition to teaching and research work at both schools, Ian will join us in the NIT [National Institute of Transplantation]/USC transplant research consortium, where we will focus on the individualization of drug therapy for transplant patients. Ian is a tremendous addition to this innovative group of scientists and clinicians.”

Hutchinson said, “I’m excited to join USC and NIT. In fact, NIT’s interest in implementing the Human Genome Project was a big attraction in my moving to California,”

Rick Selby, professor of surgery and chief of hepatobiliary and pancreatic surgery and transplantation programs in the Keck School, said, “The NIT/USC consortium is a winning combination.

“I’m hoping that our collaboration will bring an increased understanding of how we can better measure the adequacy to which patients are immunosuppressed. Right now it’s by trial and error. Having Dr. Hutchinson on our team will help us find ways to reduce complications related to medications and still have patients protected against organ rejections.”

The area of transplantation dramatically demonstrates the value of a collaborative approach between the schools of pharmacy and medicine. With both pharmacy and medical faculty working together, there is a greater chance for success in matching the right organ and the right drugs to the right patient.

“What we do in our laboratory applies to transplantation and also to drug therapy,” Hutchinson said. “We are trying to set up a test to guide doctors in their prescribing. Obviously, the ultimate choice rests with the physician, but if he or she knows that a certain drug isn’t going to work very well, then there is the option of choosing another one for a particular patient. “

Hutchinson’s transplant work involves immunogenetics, in which he studies patients’ reactions to their transplants.

“USC and NIT have good clinical research programs, making for great synergy. When you add the expertise of Ian Hutchinson, I think research development in genetics and immunology will really take off in this program. The impact of our program will be recognized nationally and internationally, and ultimately it will play a large role in improving transplant patient survival,” Burckart said.

Hutchinson will have offices at both the USC School of Pharmacy and NIT, where his lab will be located.