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Honors for University Professor Jean Shih

02/04/09
The School of Pharmacy scientist wins a National Institutes of Health grant topping $1 million and will be honored this summer by the Society of Chinese Bioscientists.
By Kukla Vera
Jean Shih is a founding member of the Society of Chinese Bioscientists in America.

Photo/Lee Salem
Jean Shih, the Boyd P. and Elsie D. Welin Professor in Pharmaceutical Sciences, has been awarded a grant of $1,096,775, continuing her research support from the National Institute of Mental Health for the next five years.

Shih’s work focuses on monoamine oxidase, also know as MAO, an enzyme that regulates brain chemicals – serotonin, dopamine and norpinephrine. These chemicals help cells communicate, affecting brain functions related to mood and behavior.

Shih’s findings have garnered international attention as her lab was the first to clone human MAO-A and MAO-B genes and to unravel their structures, functions and regulations. This work is an important building block in the development of therapeutics for aggression, anxiety and depression.

“The continuing support of the NIMH will allow us to study the developmental and environmental factors that impact brain function and behaviors. Ultimately, this will help us better identify and understand the most critical periods for prevention and treatment of these brain disorders,” said Shih, whose work has been at the forefront of neuroscience research with 32 years of consecutive funding from the National Institutes of Health.

The news about the award was complemented by the announcement that Shih will receive the Lifetime Achievement Award of the Society of Chinese Bioscientists in America. This award will be presented at the Biennial International Symposium of the Society this summer in Taipei. Shih is a founding member of the society.

Among Shih’s numerous honors are two MERIT awards from the National Institutes of Health, recognizing her distinguished scientific achievement in the research community. In 2007, she was named a fellow of the American Association for the Advancement of Science.

Shih is a professor in the Department of Pharmacology and Pharmaceutical Sciences at the School of Pharmacy and in the Department of Cell and Neurobiology at the Keck School of Medicine of USC.