Steven D. Shapiro oversees clinical care, education and research represented by USC’s academic health system, Keck Medicine of USC, and the Keck School of Medicine of USC as well as allied research and innovation endeavors throughout the university. All these health-related activities fall under the Office of Health Affairs, led by Shapiro.

Shapiro also serves as CEO of Keck Medicine. In this role, he oversees the university’s clinical activities, including USC Care Medical Group (Keck Medicine’s network of physicians who provide outpatient services and procedures); Keck Medical Center of USC, which includes Keck Hospital of USC and USC Norris Cancer Hospital; USC Verdugo Hills Hospital; USC Arcadia Hospital; and more than 100 outpatient clinics, clinical practices, and joint ventures throughout Southern and Central California as well as Las Vegas.

Shapiro works closely with USC’s senior leadership and is a member of the USC Health System Board, the governing body over Keck Medicine, the Keck School and all clinical care activities at USC. His priority is to accelerate health sciences innovation across the university through combining AI-driven technologies with transformative, compassionate patient care.

Shapiro joined USC after spending 15 years at the University of Pittsburgh Medical Center (UPMC), where he led UPMC’s health services division that encompasses more than 40 hospitals and over 7,000 employed and affiliated physicians. Before UPMC, Shapiro was the Parker B. Francis Professor of Medicine at Harvard Medical School and the chief of the Division of Pulmonary and Critical Care at Brigham and Women’s Hospital.

A physician-scientist who remained active clinically and at the lab bench, Shapiro’s research focused on novel molecular pathways of inflammation, tissue destruction and host defense in chronic obstructive pulmonary disease (COPD), infectious diseases, vascular disease and lung cancer.

He is the author of more than 230 peer-reviewed manuscripts, chapters and reviews. In addition, he was the editor-in-chief of the American Journal of Respiratory Cell and Molecular Biology and currently serves on several editorial boards.

Shapiro received his bachelor’s and doctorate degrees from the University of Chicago and his residency and fellowship at the Washington University School of Medicine in St. Louis.